以色列科學家發現 喝咖啡會縮減壽命 - 咖啡討論

大概講到端粒跟人有關係的在這一段:
Deletion of Rif1 and mutations in Rap1 also significantly decrease the
telomeric response to caffeine, indicating that Rif1-Rap1 is not only
involved in telomere elongation under ethanol stress, but also in telomere
shortening under caffeine. Caffeine is a known inhibitor of phosphatydyl
inositol-3 kinase related kinases (PI3K-like kinases) such as human ATR and
ATM [43] and their yeast counterparts, Tel1 and Mec1 [44]. Therefore, we
tested whether mutations in these target genes would abolish the telomere
shortening caused by caffeine. Indeed, deletion of either TEL1 or MEC1
individually does not prevent the response to caffeine, but a double mutant
tel1Δ mec1Δ is completely insensitive to the telomeric effect of caffeine
(Figure S5), consistent with the known redundant function that these two
kinases play in telomere biology [45]. Thus, caffeine causes telomere
shortening by inhibiting the ATM/ATR-like regulatory kinases.

不知道是不是這樣:

咖啡因--> PI3K..ATR/Mec1..ATM/Tel1的 inhibitor
-->無法進行AKT--> 無法進行cell cycle & growth程序

所以說會影響端粒的長度進而縮短壽命.....?

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